关键词:

关键词: 高脂血症模型, 脂肪乳, 对比研究, 血脂, 肝脂

Abstract:

Abstract:Objective A comparative study of hyperlipidemia models induced by fat emulsion in SD rats and KM mice was conducted in order to provide reference for the study of the pathogenesis of hyperlipidemia and the basis for the selection of animal disease models for the development of lipid-lowering drugs. Method The hyperlipidemia model was induced by gavage of fatty emulsion for 2 weeks and 4 weeks, and the four blood lipids ( TG, TC, LDLC, HDL-C) , liver fat ( TG, TC) and liver tissue lesions were detected. Result Compared with the normal group, the fat emulsion of KM mice was intragastrically administered for 2 weeks, and there was no obvious change in blood lipids. After 4 weeks of intragastric administration, the liver tissues showed mild pathological damage, but blood lipids and liver lipids remained unchanged. SD rat fat emulsion was given to the stomach for 2 weeks, serum TC and LDL-C were significantly increased (P<0. 001, P<0. 01) , HDL-C was significantly reduced (P<0. 001) , and TG had no significant change; fat emulsion was given to the stomach 4 In week, rat serum TG, TC, LDL-C were significantly increased (P<0. 001, P<0. 01) , HDL-C was significantly reduced ( P < 0. 001) , and the liver was obviously enlarged, white in color, and liver tissue lesions. The degree is heavier, with obvious fat vacuoles. Conclusion The hyperlipidemia model of SD rats induced by fat emulsion gavage for 4 weeks was better.

Key words:

Key words:hyperlipidemia model, fat emulsion, comparative study, blood lipids, liver lipids